DOK5 as a Prognostic Biomarker of Gastric Cancer Immunoinvasion: A Bioinformatics Analysis
Table 2
Correlation analysis between DOK5 and related genes and markers of immune cells in TIMER.
Description
Gene markers
STAD
None
Purity
Core
Core
CD8+ T cell
CD8A
0.319
0.277
CD8B
0.216
0.185
T cell (general)
CD3D
0.286
0.233
CD3E
0.318
0.271
CD2
0.348
0.307
B cell
CD19
0.288
0.262
CD79A
0.333
0.292
Monocyte
CD86
0.464
0.426
CD115 (CSF1R)
0.55
0.523
TAM
CCL2
0.594
0.56
CD68
0.291
0.257
IL10
0.457
0.438
M1 macrophage
INOS (NOS2)
-0.065
-0.09
IRF5
0.301
0.291
COX2 (PTGS2)
0.216
0.217
M2 macrophage
CD163
0.448
0.416
VSIG4
0.492
0.47
MS4A4A
0.526
0.501
Neutrophils
CD66b (CEACAM8)
-0.034
-0.029
CD11b (ITGAM)
0.496
0.482
CCR7
0.398
0.357
Natural killer cell
KIR2DL1
0.142
0.124
KIR2DL3
0.079
0.11
0.043
0.405
KIR2DL4
-0.017
0.73
-0.052
0.316
KIR3DL1
0.159
0.134
KIR3DL2
0.175
0.14
KIR3DL3
-0.107
-0.102
KIR2DS4
0.059
0.229
0.04
0.437
Dendritic cell
HLA-DPB1
0.394
0.35
HLA-DQB1
0.205
0.154
HLA-DRA
0.285
0.241
HLA-DPA1
0.324
0.28
BDCA-1 (CD1C)
0.455
0.431
BDCA-4 (NRP1)
0.627
0.615
CD11c (ITGAX)
0.459
0.432
Th1
T-bet (TBX21)
0.301
0.264
STAT4
0.358
0.327
STAT1
0.033
0.507
0.012
0.815
IFN-γ (IFNG)
0.064
0.196
0.0036
0.482
TNF-α (TNF)
0.158
0.109
Th2
GATA3
0.363
0.337
STAT6
0.154
0.148
STAT5A
0.384
0.383
IL13
0.179
0.207
Tfh
BCL6
0.416
0.396
IL21
0.116
0.0096
0.063
Th17
STAT3
0.336
0.337
IL17A
-0.148
-0.158
Treg
FOXP3
0.33
0.287
CCR8
0.397
0.384
STAT5B
0.462
0.457
TGFβ (TGFB1)
0.576
0.552
T cell exhaustion
PD-1 (PDCD1)
0.221
0.182
CTLA4
0.17
0.125
LAG3
0.179
0.136
TIM-3 (HAVCR2)
0.456
0.433
GZMB
0.119
0.066
0.203
STAD: stomach adenocarcinoma; TAM: tumor-associated macrophage; Th: T helper cell; Tfh: follicular helper T cell; Treg: regulatory T cell; Cor: value of Spearman’s correlation; None: correlation without adjustment; Purity: correlation adjusted by purity (,, and ).
