Research Article

Prognostic Bone Metastasis-Associated Immune-Related Genes Regulated by Transcription Factors in Mesothelioma

Table 2

Summary of 19 most significant biomarkers in external validation.
(a)

SDC2TCF7L1POLR3DCD38CD1ACYP3A4HMGCLACAT2CYP27A1
NTNTNTNTNTNTNTNTNT

GEPIANANANANANANANANANANA
ProgGeneV2NANANANANANANANANANA
UALCANNANANANANANANANANA
LinkedOmicsNANANANANANANANANA
UCSC XenaNANANANANANANANANA
CCLENANANANANANANANANA

(b)

PLB1DPYSGAD1LTC4SPTGS1BCAT1BCKDHABCKDHBACTG1
NTNTNTNTNTNTNTNTNT

GEPIANANANANANANANANANA
ProgGeneV2NANANANANANANANANA
UALCANNANANANANANANANANA
LinkedOmicsNANANANAMNANANANANAND
UCSC XenaNANANANANANANANANA
CCLENANANANANANANANANANA

(c)

ACTN1Result
NT

GEPIANASDC2, TCF7L1, POLR3D, ACAT2, GAD1, BCKDHB, ACTG1, and ACTN1 were highly expressed in MESO (Figure S1 C, F, I; Figure S3 B, F, I, J, K). CD38, CYP3A4, CYP27A1, PLB1, DPYS, LTC4S, and PTGS1 were lowly expressed in GEPIA (Figure S2 C, Figure S3 A, C, D, E, G, H).
ProgGeneV2NAIn ProgGeneV2, SDC2, TCF7L1, ACAT2, GAD1, ACTG1, and ACTN1 were expressed highly in MESO (Figure S1 E, H; Figure S4 B, E, I, J). HMGCL, CYP27A1, PLB1, LTC4S, PTGS1, and BCKDHA were expressed lowly in MESO (Figure S4 A, C, D, F, G, H).
UALCANNAIn UALCAN, POLR3D, CD1A, ACAT2, GAD1, BCAT1, ACTG1, and ACTN1 were highly expressed in MESO (Figure S1 K; Figure S2 D; Figure S5 B, F, G, H, I). CYP3A4, CYP27A1, PLB1, and DPYS were lowly expressed in MESO (Figure S5 A, C, D, E).
LinkedOmicsNAIn LinkedOmics, BCKDHB was highly expressed in MESO (Figure S6 F). HMGCL and CYP27A1 were lowly expressed in MESO (Figure S6 D, E).
UCSC XenaNAIn UCSC Xena, SDC2, TCF7L1, POLR3D, CD1A, ACAT2, and ACTN1 were highly expressed in MESO (Figure S1 D, G, J; Figure S2 E; Figure S7 C, I). CD38, CYP3A4, HMGCL, CYP27A1, PLB1, DPYS, LTC4S, and PTGS1 were lowly expressed in MESO (Figure S2 B; Figure S7 A, B, D, E, F, G, H).
CCLENAIn CCLE, ACTG1 was highly expressed in MESO and SDC2, TCF7L1, POLR3D, CD38, CD1A, CYP3A4, HMGCL, CYP27A1, PLB1, DPYS, GAD1, PTGS1, and BCKDHB were lowly expressed in MESO (Figure S8 B).

“N” was defined as normal; “T” was defined as thyroid carcinoma; “↑” was defined as a significantly high-expressed gene; “↓” was defined as a significantly low-expressed gene; “NA” was defined as “not available”; “ND” was defined as “not detached”; “-” was defined as a gene with no significant difference in expression. Abbreviations: MESO: mesothelioma; GEPIA: Gene Expression Profiling Interactive Analysis; CCLE: Cancer Cell Line Encyclopedia.