Traditional Chinese Medicine Compound Preparations Are Associated with Low Disease-Related Complication Rates in Patients with Rheumatoid Arthritis: A Retrospective Cohort Study of 11,074 Patients
Table 4
Analysis of risk factors for the four rheumatoid arthritis-related complications using the COX regression model.
Number of endpoint events
Univariate analysis
Multivariate analysis
HR
95% CI
value
HR
95% CI
value
Readmission
3253 (46.2%)
TCMCP
1510 (21.5%)
0.786
0.733-0.842
<0.001
0.793
0.740-0.850
<0.001
Age (year)
1.041
0.971-1.115
0.257
<57
1459 (20.7%)
≥57
1794 (25.5%)
Sex
0.910
0.826-1.002
0.054
Female
2767 (39.3%)
Male
486 (6.9%)
Underlying diseases
Hypertension
1043 (14.8%)
1.525
1.416-1.643
<0.001
1.519
1.410-1.636
<0.001
Diabetes
277 (3.9%)
1.091
0.965-1.234
0.165
Hyperlipidemia
85 (1.2%)
1.350
1.088-1.675
0.006
1.340
1.080-1.663
0.008
Sjogren’s syndrome
965 (13.7%)
TCMCP
414 (5.9%)
0.684
0.602-0.777
<0.001
0.674
0.593-0.766
<0.001
Age (year)
1.633
1.429-1.865
<0.001
1.605
1.404-1.835
<0.001
<57
331 (4.7%)
≥57
634 (9.0%)
Sex
1.123
0.952-1.325
0.167
Female
793 (11.3%)
Male
172 (2.4%)
Underlying diseases
Hypertension
335 (4.8%)
1.660
1.451-1.898
<0.001
1.566
1.369-1.792
<0.001
Diabetes
88 (1.3%)
1.163
0.934-1.448
0.177
Hyperlipidemia
27 (0.4%)
1.402
0.956-2.057
0.084
Surgical treatment
182 (2.6%)
TCMCP
82 (1.2%)
0.724
0.540-0.970
0.030
0.710
0.530-0.952
0.022
Age (year)
1.990
1.452-2.726
<0.001
1.947
1.416-2.677
<0.001
<57
56 (0.8%)
≥57
126 (1.8%)
Sex
1.137
0.780-1.388
0.505
Female
149 (2.1%)
Male
33 (0.5%)
Underlying diseases
Hypertension
52 (0.7%)
1.005
0.728-1.388
0.975
Diabetes
23 (0.3%)
1.581
1.021-2.448
0.040
1.366
0.878-2.126
0.167
Hyperlipidemia
8 (0.1%)
1.905
0.938-3.871
0.075
All-cause death
215 (3.1%)
TCMCP
93 (1.3%)
0.758
0.578-0.994
0.045
0.726
0.553-0.952
0.020
Age (year)
2.314
1.710-3.134
<0.001
2.060
1.509-2.812
<0.001
<57
57 (0.8%)
≥57
158 (2.2%)
Sex
1.687
1.237-2.301
0.001
1.517
1.106-2.080
0.010
Female
162 (2.3%)
Male
53 (0.8%)
Underlying diseases
Hypertension
72 (1.0%)
1.590
1.192-2.119
0.002
1.506
1.128-2.012
0.006
Diabetes
30 (0.4%)
1.880
1.278-2.766
0.001
1.596
1.080-2.358
0.019
Hyperlipidemia
5 (0.1%)
1.209
0.497-2.938
0.676
Abbreviation: TCMCP: traditional Chinese medicine compound preparation.
