Research Article

An Immunogenic Cell Death-Related Gene Signature Reflects Immune Landscape and Predicts Prognosis in Melanoma Independently of BRAF V600E Status

Figure 3

Identification of differentially expressed genes (DEGs) and underlying signal pathways in different subgroups of BRAF V600E WT SKCM cohort. (a) Volcano plot presents the distribution of DEGs quantified between ICD-high and ICD-low subgroups with threshold of and . The red dot indicates the upregulated genes, whereas the green dot denotes the downregulated genes. (b) Heatmap shows the DEGs expression in different subgroups. (c) Functional analysis based on the DEGs between the two subgroups using GO enrichment analysis. (d) Functional analysis based on the DEGs between the two subgroups using KEGG pathway analysis. (e, f) GSEA GO identifies the related signal pathways between ICD-high and ICD-low subgroups.
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