Analysis of Potential Mechanism of Herbal Formula Taohong Siwu Decoction against Vascular Dementia Based on Network Pharmacology and Molecular Docking

Table 1

Identification of candidate compounds for herbs in Taohong Siwu decoction.

Mol ID	Herb (Latin name)	Molecule name	Oral bioavailability (%)	Drug-likeness
MOL000422	Carthami Flos, Paeoniae Radix Alba	Kaempferol	41.88	0.24
MOL000449	Carthami Flos, Rehmanniae Radix Praeparata, Angelicae Sinensis Radix	Stigmasterol	43.83	0.76
MOL000359	Chuanxiong Rhizoma, Rehmanniae Radix Praeparata, Paeoniae Radix Alba	Sitosterol	36.91	0.75
MOL000358	Persicae Semen, Carthami Flos, Paeoniae Radix Alba, Angelicae Sinensis Radix	Beta-sitosterol	36.91	0.75
MOL001323	Persicae Semen	Sitosterol alpha1	43.28	0.78
MOL001328	Persicae Semen	2,3-Didehydro GA70	63.29	0.50
MOL001329	Persicae Semen	2,3-Didehydro GA77	88.08	0.53
MOL001340	Persicae Semen	GA120	84.85	0.45
MOL001342	Persicae Semen	GA121-isolactone	72.70	0.54
MOL001344	Persicae Semen	GA122-isolactone	88.11	0.54
MOL001349	Persicae Semen	4a-Formyl-7alpha-hydroxy-1-methyl-8-methylidene-4aalpha,4bbeta-gibbane-1alpha,10beta-dicarboxylic acid	88.60	0.46
MOL001351	Persicae Semen	Gibberellin A44	101.61	0.54
MOL001352	Persicae Semen	GA54	64.21	0.53
MOL001353	Persicae Semen	GA60	93.17	0.53
MOL001355	Persicae Semen	GA63	65.54	0.54
MOL001358	Persicae Semen	Gibberellin 7	73.80	0.50
MOL001360	Persicae Semen	GA77	87.89	0.53
MOL001361	Persicae Semen	GA87	68.85	0.57
MOL001368	Persicae Semen	3-O-p-Coumaroylquinic acid	37.63	0.29
MOL000493	Persicae Semen	Campesterol	37.58	0.71
MOL000296	Persicae Semen	Hederagenin	36.91	0.75
MOL002694	Carthami Flos	4-[(E)-4-(3,5-Dimethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)but-2-enylidene]-2,6-dimethoxycyclohexa-2,5-dien-1-one	48.47	0.36
MOL002695	Carthami Flos	Lignan	43.62	0.65
MOL002710	Carthami Flos	Pyrethrin II	48.36	0.35
MOL002712	Carthami Flos	6-Hydroxykaempferol	62.13	0.27
MOL002714	Carthami Flos	Baicalein	33.52	0.21
MOL002717	Carthami Flos	qt_carthamone	51.03	0.20
MOL002721	Carthami Flos	Quercetagetin	45.01	0.31
MOL002757	Carthami Flos	7,8-Dimethyl-1H-pyrimido[5,6-g]quinoxaline-2,4-dione	45.75	0.19
MOL002773	Carthami Flos	Beta-carotene	37.18	0.58
MOL002776	Carthami Flos	Baicalin	40.12	0.75
MOL000006	Carthami Flos	Luteolin	36.16	0.25
MOL000098	Carthami Flos	Quercetin	46.43	0.28
MOL001771	Carthami Flos	Poriferast-5-en-3beta-ol	36.91	0.75
MOL000953	Carthami Flos	CLR	37.87	0.68
MOL001924	Paeoniae Radix Alba	Paeoniflorin	53.87	0.79
MOL000211	Paeoniae Radix Alba	Mairin	55.38	0.78
MOL000492	Paeoniae Radix Alba	(+)-Catechin	54.83	0.24
MOL001919	Paeoniae Radix Alba	(3S,5R,8R,9R,10S,14S)-3,17-Dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-15,16-dione	43.56	0.53
MOL000433	Chuanxiong Rhizoma	FA	68.96	0.71
MOL001494	Chuanxiong Rhizoma	Mandenol	42.00	0.19
MOL002135	Chuanxiong Rhizoma	Myricanone	40.60	0.51
MOL002140	Chuanxiong Rhizoma	Perlolyrine	65.95	0.27
MOL002157	Chuanxiong Rhizoma	Wallichilide	42.31	0.71