Ease to Challenges in Achieving Successful Synthesized Schiff Base, Chirality, and Application as Antibacterial Agent

Table 13

Minimum inhibitory concentration (MIC) of the antibacterial activities of Schiff bases (6a–6e) and metal complexes (7a–7j) [74].

Sr No.	Sample	E. aureus		E. coli		B. subtilis
		200 μg/ml	100 μg/ml	200 μg/ml	100 μg/ml	200 μg/ml	100 μg/ml
1	6a	1.10	0.95	1.20	1.00	1.00	0.90
2	6b	1.20	1.00	1.10	1.00	1.10	0.90
3	6c	1.10	1.00	1.20	1.00	1.20	1.00
4	6d	1.20	1.00	0.95	0.80	0.95	0.85
5	6e	0.90	0.70	0.80	0.70	1.00	0.90
6	7a	1.20	1.00	0.95	0.80	0.95	0.85
7	7b	0.90	0.90	0.95	0.90	0.90	0.80
8	7c	0.95	0.85	0.95	0.90	1.00	0.90
9	7d	1.00	0.80	1.00	0.90	0.90	0.85
10	7e	1.00	0.90	0.85	0.80	0.85	0.75
11	7f	1.50	1.20	1.00	0.90	0.95	0.90
12	7g	0.90	0.90	1.10	0.90	1.20	0.90
13	7h	1.00	0.80	1.20	1.00	1.00	0.90
14	7i	0.95	0.85	1.20	1.10	1.20	1.00
15	7j	1.10	1.00	1.50	1.50	1.30	1.10
16	Penicillin	—	2.00	—	0.80	—	1.00
17	Streptomycin	—	0.70	—	0.70	—	3.00

Sr No.: serial number; 6a: (E)-ethyl5-(2-hydroxybenzylideneamino) benzofuran-2-carboxylate; 6b: (E)-ethyl5-(5-chloro-2-hydroxybenzylideneamino)benzofuran-2-carboxylate; 6c: (E)-ethyl5-(5-bromo-2-hydroxybenzylideneamino)benzofuran-2-carboxylate; 6d: (E)-ethyl5-(2-hydroxy-5-nitrobenzylideneamino)benzofuran-2-carboxylate; 6e: (E)-ethyl5-((1-hydroxynaphthalen-2yl)methyleneamino)benzofuran-2-carboxylate; 7a-7e: copper(II) complexes; and 7f-7j: zinc (II) complexes [74].