Ease to Challenges in Achieving Successful Synthesized Schiff Base, Chirality, and Application as Antibacterial Agent

Table 2

Schiff base 1 catalytic reaction of the asymmetric addition of diethylzinc to aldehydes [24].

Entry	Ligand	Aldehyde	Time (h)	Yield (%)	e.e (%)^b/config.^c
1	1	o-Methoxybenzaldehyde	72	38	16 (R)
2	1	m-Methoxybenzaldehyde	72	78	23 (R)
3	1	p-Methoxybenzaldehyde	72	61	39 (R)
4	1	o-Chlorobenzaldehyde	72	80	24 (R)
5	1	o-Bromobenzaldehyde	72	52	15 (R)
6	1	m-Chlorobenzaldehyde	72	92	94 (S)
7	1	p-Chlorobenzaldehyde	72	75	53 (S)
8	1	p-Bromobenzaldehyde	72	90	96 (S)
9	1	p-Dimethylaminobenzaldehyde	72	89	—
10	1	Cyclohexanecarboaldehyde	72	94	30 (S)