Research Progress of m⁶A RNA Methylation in Skin Diseases

Figure 2

Mechanistic illustrations of the regulatory and functional roles of m⁶A in melanoma. Several m⁶A regulators including METTL3, YTHDF1, HNRNPA2B1, FTO, and IGF2BP3 are involved in melanoma. METTL3 increases mRNA level of UCK2 through m⁶A methylation to enhance its stability in melanoma. Then, UCK2 promotes the migration and invasion ability of melanoma cells by activating the Wnt/β-catenin pathway. METTL3 also accelerates invasion and migration of melanoma cells by elevating MMP2 expression. In addition, YTHDF1 or HNRNPA2B1 promotes p53 signal pathway via m⁶A methylation to tumorgenesis. FTO reduces m⁶A methylation to inhibit gene expressions including PD-1, CXCR4, and SOX10 but stimulate melanoma growth in melanoma cells. IGF2BP3 promotes proliferation and migration of melanoma cells.