Association of RNA m7G Modification Gene Polymorphisms with Pediatric Glioma Risk
Table 1
Association of m7G modification genes and glioma risk in Chinese children.
Gene
Polymorphism
Allele
Case ()
Control ()
AOR (95% CI)a
a
AOR (95% CI)b
b
HWE
A
B
AA
AB
BB
AA
AB
BB
METTL1
rs2291617
G
T
127
129
56
155
175
50
1.00 (0.74-1.36)
0.984
1.42 (0.94-2.16)
0.098
0.956
METTL1
rs10877013
T
C
134
128
50
160
175
45
0.97 (0.71-1.31)
0.837
1.39 (0.90-2.15)
0.142
0.786
METTL1
rs10877012
T
G
129
128
55
152
180
48
0.95 (0.70-1.29)
0.742
1.45 (0.95-2.21)
0.086
0.639
WDR4
rs2156315
C
T
184
113
15
232
135
13
1.10 (0.81-1.50)
0.535
1.47 (0.69-3.14)
0.324
0.213
WDR4
rs2156316
C
G
146
144
22
163
186
31
0.86 (0.64-1.16)
0.323
0.85 (0.48-1.50)
0.563
0.027
WDR4
rs6586250
C
T
261
51
0
301
74
5
0.74 (0.50-1.09)
0.124
/
/
0.852
WDR4
rs15736
G
A
266
46
0
299
76
5
0.63 (0.42-0.94)
0.023
/
/
0.945
WDR4
rs2248490
C
G
148
143
21
165
184
31
0.86 (0.63-1.16)
0.309
0.80 (0.45-1.43)
0.457
0.039
AOR: adjusted odds ratio; CI: confidence interval; HWE: Hardy–Weinberg equilibrium. aAdjusted for age and gender for dominant model. bAdjusted for age and gender for recessive model.
