Shotgun Metagenomic Analyses of Microbial Assemblages in the Aquatic Ecosystem of Winam Gulf of Lake Victoria, Kenya Reveals Multiclass Pollution

Figure 12

Drug and enzyme metabolism pathways show microbial genes like 3.4.2.8 hypoxanthine phosphoribosyl transferases responsible for drug metabolism and degradation of azathioprine, 6-thiguanine, and 5-triphosphate inactivating drug ingredients. 3.1.1.1 carboxylestrase keg orthogus genome is responsible for drug metabolism and biodegradation of irinotecam to 3.2.1.31 beta-glucuronide which is responsible for its biodegradation, thus inactivating the drug-active ingredients. 2.7.1.21 thymidine kinase is responsible for xenobiotic biodegradation and drug metabolism.