Lumbrokinase, a Fibrinolytic Enzyme, Prevents Intra-Abdominal Adhesion by Inhibiting the Migrative and Adhesive Activities of Fibroblast via Attenuation of the AP-1/ICAM-1 Signaling Pathway

Figure 2

Peritoneal thickness in normal and injured areas. (a) After one week of injury, peritoneum tissue from noninjured and injured areas was obtained and stained with hematoxylin and eosin (H&E). The reduction in peritoneal thickness occurred in a dose-dependent manner. Scale bar, 100 μm. A monolayer of mesothelial cells was observed in the normal peritoneum from the noninjured peritoneum (arrow). The peritoneum of the injured area was thickened in the nontreated group, whereas peritoneal thickness was significantly reduced in the lumbrokinase-treated groups. (b) Quantification of the peritoneal thickness. The thickness measurement is the average obtained at four different sites in each rat based on image analysis with the ImageJ software ( value for the indicated groups compared with the control).

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