Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia

Table 3

Effect of flumazenil on the antiseizure activity of Peganum harmala L. and diazepam in pentylenetetrazol- (PTZ-) induced seizures in mice^a.

Treatment	Dose	Seizure latency (sec)	Tonic-clonic onset (sec)	Seizure duration (sec)	Death time (sec)	Mortality protection rate (%)
Normal saline	10 ml/kg					0
Diazepam	2 mg/kg	—	—	—	—	100
Diazepam+flumazenil	2 mg/kg, 2 mg/kg				—	90
P. harmala	10 mg/kg				—	90
Peganum harmala+flumazenil	10 mg/kg, 2 mg/kg				—	90
value	—	0.001^+	0.048^+	0.000^+	—	—
Test statistic	—	6.756^+	2.924^+	20.302^+	—	—

⁺ values and test statistics () refer to one-way ANOVA test. and compared with the normal saline group; refer to Tukey’s post hoc test. ^aThe results of post hoc analyses that compare the effects of Peganum harmala and Peganum harmala+flumazenil are indicated in Figure 2.