Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia

Table 6

Effect of flumazenil on the antiseizure activity of Lavandula angustifolia and diazepam in pentylenetetrazol- (PTZ-) induced seizures in mice^a.

Treatment	Dose (mg/kg)	Latency to seizure onset (sec)	Tonic-clonic onset (sec)	Seizure duration (sec)	Death time (sec)	Mortality protection rate (%)
Normal saline	10 ml/kg					0
Diazepam	2 mg/kg	—	—	—	—	100
Diazepam+flumazenil	2 mg/kg, 2 mg/kg				—	90
L. angustifolia	600 mg/kg				—	90
L. angustifolia+flumazenil	600 mg/kg, 2 mg/kg					50
value	—	0.001^#	0.000^+	0.000^#	0.269^##	—
Test statistic	—	17.534^#	18.580^+	23.930^#	16.000^##	—

^# values and test statistics (H) refer to the Kruskal-Wallis test. ⁺ values and test statistics () refer to one-way ANOVA test. ^## values and test statistics () refer to the Mann–Whitney U test. and compared with the normal saline group; refer to the post hoc tests (Dunn’s test for the Kruskal-Wallis test and Tukey’s test for one-way ANOVA). ^aThe results of post hoc analyses that compare the effects of L. angustifolia and L. angustifolia+flumazenil are indicated in Figure 3.