Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia

Table 7

Effect of naloxone on the antiseizure activity of Lavandula angustifolia in pentylenetetrazol- (PTZ-) induced seizures in mice^a.

Treatment	Dose (mg/kg)	Seizure latency (sec)	Tonic-clonic onset (sec)	Seizure duration (sec)	Death time (sec)	Mortality protection rate (%)
Normal saline	10 ml/kg					0
Naloxone	5 mg/kg					20
L. angustifolia	600 mg/kg				—	90
L. angustifolia+naloxone	600 mg/kg, 5 mg/kg					60
value	—	0.000^+	0.000^+	0.000^+	0.401^+	—
Test statistic	—	20.752^+	18.889^+	15.433^+	0.954^+	—

⁺ values and test statistics () refer to one-way ANOVA test. compared with the normal saline group; refer to the post hoc tests (Tukey’s post hoc test). ^aThe results of post hoc analyses that compare the effects of L. angustifolia and L. angustifolia+naloxone are indicated in Figure 3.