Preclinical Demonstration of a Novel Treatment with High Efficacy and No Detectable Toxicity for Inflammatory Skin Conditions including Psoriasis

Table 1

Effects of allopurinol on cell number and viability in the M5-HaCaT model of psoriasis.

(a)

Time (hrs)	Treatment	Total cell count
		Live	Dead	Total
0	Ctrl	^B	^G	^EF
48	Ctrl	^A	^DE	^B
48	ALLO 0.5	^B	^EF	^D
48	ALLO 3	^C	^FG	^F
48	MTX	^D	^BC	^DE
72	Ctrl	^A	^B	^A
72	ALLO 0.5	^B	^CD	^C
72	ALLO 3	^C	^EF	^F
72	MTX	^E	^A	^D

(b)

Time (hrs)	Treatment	Relative to initial live cells
		Total	Dead
0	Ctrl	^EF	^G
48	Ctrl	^B	^DE
48	ALLO 0.5	^D	^EF
48	ALLO 3	^F	^FG
48	MTX	^DE	^BC
72	Ctrl	^A	^B
72	ALLO 0.5	^C	^CD
72	ALLO 3	^F	^EF
72	MTX	^D	^A

Values are (). Means with different letters are significantly different (, Tukey’s multicomparison test).