The Effect of Citrus aurantium on Non-Small-Cell Lung Cancer: A Research Based on Network and Experimental Pharmacology

Table 2

54 potential target genes of Citrus aurantium therapy for NSCLC.

No.	Target	Symbol	UniProt ID
1	Prostaglandin G/H synthase 1	PTGS1	P23219
2	Prostaglandin G/H synthase 2	PTGES3	Q15185
3	Heat shock protein HSP 90	HSPB1	P04792
4	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform	PIK3CG	P48736
5	mRNA of PKA catalytic subunit C-alpha	AKAP13	Q12802
6	Nuclear receptor coactivator 1/nuclear receptor coactivator 2	BUD23	O43709
7	Progesterone receptor	NR3C2	P08235
8	Muscarinic acetylcholine receptor M3	CHRM3	P20309
9	Muscarinic acetylcholine receptor M1	CHRM1	P11229
10	CGMP-inhibited 3,5-cyclic phosphodiesterase A	PDE3A	Q14432
11	Muscarinic acetylcholine receptor M2	CHRM2	P08172
12	Neuronal acetylcholine receptor subunit alpha-2	CHRNA3	P32297
13	Mu-type opioid receptor	OPRM1	P35372
14	Cytochrome P450-cam	FGFR4	P22455
15	Apoptosis regulator Bcl-2/apoptosis regulator BAX	BCL2L1	Q07817
16	Caspase-9	CASP9	P55211
17	Transcription factor AP-1	ESR1	P03372
18	Caspase-8	CARD8	Q9Y2G2
19	Transforming growth factor beta-1	LYN	P07948
20	Serum paraoxonase/arylesterase 1	PON1	P27169
21	Microtubule-associated protein 2	MAP4	P27816
22	Transcription factor p65	CDK9	P50750
23	RAC-alpha serine/threonine-protein kinase	BCR	P11274
24	Mitogen-activated protein kinase 1/mitogen-activated protein kinase 3	MAPK14	Q16539
25	Bcl2 antagonist of cell death	MAPK8	P45983
26	Catalase	CAT	P04040
27	Peroxisome proliferator-activated receptor gamma	PPARA	Q07869
28	Apolipoprotein B-100	APOB	P04114
29	Phospholipase B1, membrane-associated	SNCA	P37840
30	3-Hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	P04035
31	Cytochrome P450 19A1	CYP19A1	P11511
32	Glutathione S-transferase P	GSTP1	P09211
33	UDP-glucuronosyltransferase 1-1	UGT1A1	P22309
34	Glutathione reductase, mitochondrial	GSTO1	P78417
35	Adiponectin	ADIPOQ	Q15848
36	Aldo-keto reductase family 1 member C1	AKR1C2	P52895
37	Liver carboxylesterase 1	CES1	P23141
38	Nitric oxide synthase, inducible	NOS2	P35228
39	Thrombin	CXCL8	P10145
40	Androgen receptor	PKN1	Q16512
41	Coagulation factor Xa/coagulation factor VII	F2RL1	P55085
42	mRNA of protein-tyrosine phosphatase, nonreceptor type 1	PTPN22	Q9Y2R2
43	DNA topoisomerase II	DHX9	Q08211
44	Estrogen receptor beta	PDGFRB	P09619
45	Dipeptidyl peptidase IV	DPP4	P27487
46	Serine/threonine-protein kinase Chk1	CDK1	P06493
47	Trypsin-1	PRSS1	P07477
48	Calcium-activated potassium channel subunit alpha 1	KCNMA1	Q12791
49	Glycogen synthase kinase-3 beta	GSK3B	P49841
50	Matrix metalloproteinase-9	MMP9	P14780
51	Cellular tumor antigen p53	TP53	P04637
52	Cytosolic phospholipase A2	ANXA3	P12429
53	Scavenger receptor cysteine-rich type 1 protein M130	CD163	Q86VB7
54	Ephrin type-B receptor 2	MMP2	P08253