Whole-Transcriptome Sequencing Combined with High-Dimensional Proteomic Technologies Reveals the Potential Value of miR-135b-5p as a Biomarker for Hepatocellular Carcinoma

Figure 1

The expression of miR-135b-5p in HCC and its association with prognosis. (a) Volcano plot shows DEmiRNAs between the AFP-high and AFP-low groups. (b) Volcano plot shows DEmiRNAs between the CA and CP groups. (c) Venn diagram shows the number of common DEmiRNAs. (d) The Kaplan-Meier curves show the OS of patients, characterized by low or high expression of indicated miRNA (based on the median expression level of each miRNA). (e) Forest plot shows the risk factors evaluated by the univariate Cox proportional hazard regression model. (f) Forest plots show the risk factors evaluated by the univariate (top) or multivariate (bottom) Cox proportional hazard regression model. (g) qRT-PCR quantifies the expression of miR-135b-5p in the AFP-high and AFP-low groups. .

(a)

(b)

(c)

(d)

(e)

(f)

(g)