Rutin-Rich Flavonoid Subfraction of <i>Annona senegalensis</i> Mitigates <i>Trypanosoma brucei brucei</i> Infection and Hematobiochemical Changes in Infected Mice

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left">Polyphenol</td><td class="align_center">RT</td><td class="align_center">ppm</td><td class="align_center">Area (<span class="nowrap"><svg height="10.335pt" id="M75" style="vertical-align:-0.2325001pt" version="1.1" viewbox="-0.0498162 -10.1025 40.2751 10.335" width="40.2751pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M797 0V26C739 32 732 36 732 103V296C732 394 682 449 605 449C576 449 550 437 529 423C504 407 475 389 446 366C425 418 382 449 334 449C303 449 279 437 253 421C222 403 201 385 180 371V452C135 432 85 419 41 411V388C99 379 102 374 102 310V103C102 38 93 32 27 26V0H238V26C189 32 180 38 180 103V338C210 363 250 390 289 390C351 390 377 348 377 275V103C377 37 368 32 306 26V0H520V26C465 32 456 38 456 101V296C456 314 455 326 453 338C491 369 529 390 565 390C628 390 653 345 653 274V107C653 36 642 32 583 26V0H797Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.647,0)"><path d="M673 0V28C608 34 594 43 563 129C499 303 432 494 370 665L339 656L132 132C98 43 84 37 20 28V0H238V28C162 35 154 45 175 108C188 150 203 192 219 237H432C454 176 474 122 487 83S491 36 428 28V0H673ZM418 280H234C265 362 296 450 328 535H330L418 280Z"></path></g><g transform="matrix(.013,0,0,-0.013,19.704,0)"><path d="M716 650H478V622C549 617 570 605 575 566C579 535 582 493 582 401V326C582 161 537 40 393 40C269 40 205 133 205 294V521C205 611 213 617 291 622V650H33V622C111 615 120 611 120 521V272C120 154 148 80 208 34C252 0 309 -14 368 -14C434 -14 501 7 548 55C605 116 623 201 623 319V401C623 493 626 536 629 563C633 605 656 618 716 622V650Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,29.308,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g><g transform="matrix(.013,0,0,-0.013,35.387,0)"><path d="M319 325C317 349 306 409 297 431C277 440 250 449 209 449C117 449 57 389 57 319C57 243 122 209 182 182C232 159 261 135 261 91C261 48 227 21 190 21C130 21 85 79 68 145L41 140C41 104 51 36 58 22C75 7 121 -12 172 -12C252 -12 337 35 337 126C337 195 286 231 210 262C166 281 126 304 126 348C126 388 152 417 191 417C240 417 274 378 294 318L319 325Z"></path></g></svg>)</span></td><td class="align_center">Amount area</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">Gallic acid</td><td class="align_center">4.398</td><td class="align_center">5.78038<span class="nowrap"><svg height="6.1673pt" id="M76" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>1.</td><td class="align_center">53.0048</td><td class="align_center">1.09054<span class="nowrap"><svg height="6.1673pt" id="M77" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>2</td></tr><tr><td class="align_left">Rutin</td><td class="align_center">22.261</td><td class="align_center">65.34865</td><td class="align_center">829.70630</td><td class="align_center">7.87612<span class="nowrap"><svg height="6.1673pt" id="M78" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>2</td></tr><tr><td class="align_left">Quercetin</td><td class="align_center">37.278</td><td class="align_center">7.29051<span class="nowrap"><svg height="6.1673pt" id="M79" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>1</td><td class="align_center">12.31526</td><td class="align_center">5.91990<span class="nowrap"><svg height="6.1673pt" id="M80" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>2</td></tr><tr><td class="align_left">Kaempferol</td><td class="align_center">38.33</td><td class="align_center">1.52028</td><td class="align_center">23.65234</td><td class="align_center">6.42762<span class="nowrap"><svg height="6.1673pt" id="M81" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>2</td></tr><tr><td class="align_left">Luteolin</td><td class="align_center">39.173</td><td class="align_center">32.77736</td><td class="align_center">197.31702</td><td class="align_center">1.66115<span class="nowrap"><svg height="6.1673pt" id="M82" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -5.96091 5.50181 6.1673" width="5.50181pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M391 364C391 409 353 448 295 448C249 448 198 426 152 393C65 331 23 225 23 139C23 14 96 -12 146 -12C198 -12 280 9 367 101L351 124C300 78 242 48 194 48C129 48 109 107 109 162V191C208 213 391 266 391 364ZM313 350C313 305 268 261 113 223C132 334 187 381 217 398C227 404 244 405 261 405C290 405 313 385 313 350Z"></path></g></svg>-</span>1</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Polyphenolic compounds identified from the subfraction 3 flavonoid of <i>A. senegalensis</i>.</div>

BioMed Research International

tab5

Table 5

Table 5: Rutin-Rich Flavonoid Subfraction of <i>Annona senegalensis</i> Mitigates <i>Trypanosoma brucei brucei</i> Infection and Hematobiochemical Changes in Infected Mice 

Table 5 | Rutin-Rich Flavonoid Subfraction of Annona senegalensis Mitigates Trypanosoma brucei brucei Infection and Hematobiochemical Changes in Infected Mice 