Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?

Table 5

PK parameters of single-dose injection or maintenance dosing after ciprofol infusion.

PK parameters	Dosage
	Single dose of 0.4 mg/kg [22] median (Q1, Q3)	Initial infusion 1 mg/kg/h for for 3.5 h [23] mean (CV%)	Bolus-loading dose for 12 h [23] mean (CV%)
(ng/mL)	1330.0 (985.0, 1710.0)	550.7 (13.4)	1282.4 (83.9)
(ng·h/mL)	254.33 (226.67, 423.33)	2496.4 (46.3)	4417.9 (12.7)
(ng·h/mL)	271.67 (245.00, 505.00)	2211.6 (16.5)	4647.2 (13.2)
(min)	2.00 (2.00, 3.00)	55.20 (30.00, 720.00)^#	3.60 (1.80, 17.40)^#
(h)	2.09 (1.86, 2.47)	12.78 (41.7)	9.91 (17.3)
(L/h/kg)	1.47 (0.79, 1.63)	1.00 (19.0)	1.09 (22.9)
(L/kg)	4.3 (2.1, 5.0)	18.94 (49.7)	15.45 (21.7)
(L/h)	0.34 (0.28, 0.37)	0.061 (32.8)	0.072 (15.3)
(h)	2.36 (1.89, 2.37)	3.68 (62.5)	3.31 (16.9)

Notes: ^#these data of are presented as median (range). Abbreviations: PK: pharmacokinetics; : maximum plasma concentration; AUC: area under the curve; CV: coefficient of variation; : time of maximum plasma concentration; : terminal elimination half-life; CL: clearance after adjusting for weight; Vd: apparent volume of distribution; : elimination rate constant; MRT: mean residence time.