Review Article
Ciprofol: A Novel Alternative to Propofol in Clinical Intravenous Anesthesia?
Table 6
Incidence of adverse events of ciprofol and propofol.
| | Clinical trials | Groups | Any TEAEs (, %) | | Drug-related TEAEs (, %) | | Pain on injection (, %) | |
| | Phase I clinical study in healthy subjects [23] | Ciprofol () | 6 (75.0) | — | 5 (62.5) | — | 1 (12.5) | — | | Propofol () | 8 (100) | 8 (100) | 7 (87.5) | | Sedation/anesthesia in patients undergoing colonoscopy [24] | Ciprofol () | 26 (83.9) | 0.300 | 15 (48.4) | 0.133 | 4 (12.9) | — | | Propofol () | 26 (83.9) | 19 (61.3) | 14 (45.2) | | Induction of deep sedation during gastroscopy and colonoscopy procedures [25] | Ciprofol () | 109 (75.7) | 0.201 | 41 (28.5) | 0.403 | 7 (4.9) | <0.001 | | Propofol () | 100 (69.0) | 35 (24.1) | 76 (52.4) | | Anesthesia/sedation in patients undergoing fiber-optic bronchoscopy [26] | Ciprofol () | 71 (52.6) | <0.001 | 50 (37.0) | <0.001 | 6 (4.4) | <0.001 | | Propofol () | 101 (76.5) | 93 (70.5) | 52, (39.4) | | Induction and maintenance of general anesthesia in elective surgical patients [27] | Ciprofol () | 30 (100) | — | 23 (76.7) | — | — | — | | Propofol () | 9 (90.0) | 8 (80.0) | | Propofol+ciprofol () | 6 (100) | 4 (66.7) | | Anesthesia in patients scheduled for elective surgery [28] | Ciprofol () | 78 (88.6) | 0.160 | 70 (79.4) | — | 6 (6.8) | 0.014 | | Propofol () | 84 (95.5) | 79 (89.7) | 18 (20.5) | | Sedation in ICU patients with mechanical ventilation [29] | Ciprofol () | 17 (65.4) | 0.276 | 2 (7.7) | 0.153 | — | — | | Propofol () | 11 (84.6) | 4 (30.8) | — |
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Abbreviations: TEAEs: treatment-emergent adverse events.
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