The Effect of Different Luteal Phase Support Applications on Clinical Pregnancy Outcomes in Frozen-Thawed Embryo Transfer

Table 5

Demographic data and treatment outcomes for females aged >35 years for different luteal phase support agents.

	Age group (>35)
	Total	Vaginal P4 gel	Oral P4 tb	P4 IM
	()	()	()	()
Age median (min/max)	39 (35/45)	40 (35/45)	38 (35/41)	39 (35/44)	0.270^k
BMI median (min/max)	25.38 (19.5/40)	24.78 (21/40)	24.5 (19.5/29.3)	26 (19.72/38.25)	0.211^k
The cause of infertility (%)					0.302^f^f
Male	12 (18.8)	3 (15)	2 (15.4)	7 (22.6)
Female	39 (60.9)	16 (80)	7 (53.8)	16 (51.6)
Male and female	8 (12.5)	0 (0)	3 (23.1)	5 (16.1)
Unknown	5 (7.8)	1 (5)	1 (7.7)	3 (9.7)
Pregnancy (%)	28 (43.8)	4 (20)	6 (46.2)	18 (58.1)^a	0.031^c
Endometrium (mm) median (min/max)	9.8 (7/14)	9.75 (7/12.9)	10 (8/13)	9.5 (7/14)	0.715^k
Number of attempts (n) median (min/max)	1 (1/8)	1 (1/8)	1 (1/4)	2 (1/6)	0.850^k
FSH (mlU/ml) median (min/max)	7.96 (3.84/23.77)	9.12 (4.19/19.44)	8.4 (4.73/18.2)	6.86 (3.84/23.77)	0.221^k
LH(IU/L) median (min/max)	4.97 (0.51/12.24)	4.27 (2.43/10)	6.87 (0.51/10.7)	4.66 (0.96/12.24)	0.079^k
AMH (ng/ml) median (min/max)	1.25 (0.01/11.88)	1.3 (0.15/8)	1.1 (0.07/6.5)	1.2 (0.01/11.88)	0.919^k
TSH (milliliter) mean (SD)	1.95 (0.89)	1.77 (0.84)	1.97 (0.73)	2.06 (0.98)	0.484^f
E2 (pg/ml) median (min/max)
Basal	41.48 (12.68/85)	35.79 (21.99/81)	45.3 (31.4/85)	40.13 (12.68/76.93)	0.262^k
Transfer	344.5 (105.4/979)	337.5 (105.4/829)	350 (231/643)	344 (134.1/979)	0.791^k
Difference (transfer-basal)	300.52 (69.62/951.1)	307.16 (69.62/748)	295.9 (182.4/592.9)	304.87 (110.9/951.1)	0.807^k
value for basal vs. transfer	<0.001ᵚ	<0.001ᵚ	<0.001ᵚ	<0.001ᵚ
Progesterone (ng/ml) median (min/max)
Basal	0.55 (0.14/1.76)	0.52 (0.14/1.51)	0.76 (0.26/1.04)	0.48 (0.21/1.76)	0.129^k
Transfer	15 (1.28/78)	9.47 (3.13/78)	16.8 (7.8/60)^a	18 (1.28/60)^a	0.009^k
Difference (transfer-basal)	14.46 (0.8/77.7)	8.86 (2.49/77.7)	15.93 (7.04/59.24)^a	17.3 (0.8/59.12)	0.010^k
p value for basal vs. transfer	<0.001ᵚ	<0.001ᵚ	<0.001ᵚ	<0.001ᵚ

^kKruskal Wallis H test (Monte Carlo), Post Hoc test: Dunn’s test, ^ffFisher Freeman Halton test (Monte Carlo), ^fOne-way ANOVA test (Boostrap), ^cPearson Chi-Square test (Monte Carlo), ^ᵚWilcoxon test (Monte Carlo), ^aexpresses significance according to Crinone, SD: standart deviation; min: minimum; max: maximum.