Antimalarial Efficacy and Safety of Senna occidentalis (L.) Link Root Extract in Plasmodium berghei-Infected BALB/c Mice

Table 2

Weight changes in Plasmodium berghei infected and uninfected BALB/c mice administered with Senna occidentalis methanolic root extract.

Experimental groups	Weight (g) day 0 (infection day)	Weight (g) on day 4 postinfection	Weight (g) on day (8 postinfection)	Change in body weight (g)	Percentage change in weight
A	27.21 ± 0.32	27.16 ± 0.65	25.23 ± 0.44 (0.01^p)	-1.98	7.28
B	28.4 ± 0.51	28.21 ± 0.34	26.20 ± 0.30 (0.01^p)	-2.20	7.75
C	27.73 ± 0.57	27.69 ± 0.86	28.65 ± 0.92 (0.42^p)	+0.92	3.32
D	27.75 ± 0.48	27.63 ± 0.37	24.50 ± 0.76 (0.01^p)	-3.25	11.71
E	28.12 ± 0.82	28.85 ± 0.66	29.45 ± 0.61 (0.23^p)	+1.33	4.72
F	27.84 ± 0.72	28.53 ± 0.71	29.13 ± 0.83 (0.27^p)	+1.29	4.63

A: infected and given methanolic extract (100 mg/kg); B: infected and given methanolic extract (200 mg/kg); C: infected and given pyrimethamine; D: infected and given PBS; E: not infected but given extract (200 mg/kg); F: not infected but given PBS; ^p value; -:decrease; +:increase.