Antimalarial Efficacy and Safety of Senna occidentalis (L.) Link Root Extract in Plasmodium berghei-Infected BALB/c Mice
Table 4
Red blood cell indices in Plasmodium berghei-infected and uninfected BALB/c mice administered with Senna occidentalis methanolic root extract.
Red blood cell indices
Experimental groups
A
B
C
D
E
F
RBCs (1012/l)
5.56 ± 1.21
6.92 ± .11
7.15 ± 0.34
5.48 ± 0.67
7.59 ± 0.28
7.55 ± 0.05
HGB (g/dl)
10.45 ± 0.65
12.65 ± 0.25(p)
12.9 ± 0.3(p)
9.3 ± 0.9
13.3 ± 0.3
13.4 ± 0
HCT (%)
38.1 ± 3
38.7 ± 0.65
41.5 ± 1.8
33.65 ± 3.45
44.9 ± 2.7
43.4 ± 0.3
MCV (fl)
70.7 ± 10
58.1 ± 0.35
58.1 ± 0.2
61.55 ± 1.25
59.1 ± 1.4
57.5 ± 0.8
MCH (pg)
19.4 ± 3
14.2 ± 3.5
18.1 ± 0.4
17.05 ± 0.45
17.5 ± 0.3
17.75 ± 0.15
MCHC (g/dl)
27.45 ± 0.35
24.45 ± 8.13
31.1 ± 0.5
27.65 ± 0.15
29.7 ± 1.2
30.8 ± 0.2
RDW-SD (fl)
27.35 ± 4.65
21 ± 0(p)
20.75 ± 0.65(p)
30.75 ± 2.05
21.5 ± 0.9
21.1 ± 0.5
(p)Statistically significant change; A: infected and given methanolic extract (100 mg/kg); B: infected and given methanolic extract (200 mg/kg); C: infected and given pyrimethamine; D: infected and given PBS; E: not infected but given extract (200 mg/kg); F: not infected but given PBS.
