Antimalarial Efficacy and Safety of Senna occidentalis (L.) Link Root Extract in Plasmodium berghei-Infected BALB/c Mice

Table 6

Kidney function indices in P. berghei-infected and uninfected BALB/c mice administered Senna occidentalis methanolic root extract.

Kidney function parameters	Experimental groups
	A	B	C	D	E	F
Sodium (mmol/L)	156.5 ± 2.5	160.3 ± 1.5	159 ± 2	153.5 ± 0.5	155 ± 1	153 ± 2
Potassium (mmol/L)	9.95 ± 0.75	12.9 ± 1.45	10.35 ± 0.15	12.35 ± 2.42	10.9 ± 0.3	10.65 ± 2.05
Chloride (mmol/L)	106 ± 3	110 ± 2	110 ± 5	109.5 ± 0.5	112 ± 1	105 ± 2
Urea (mmol/L)	2.9 ± 0.2^(p^)	3.45 ± 0.15	2.9 ± 0.1^(p^)	3.9 ± 0.2	2.35 ± 0.25	2.1 ± 0.2
Creatinine (Umol/L)	55.8 ± 2.5^(p^)	53.75 ± 2.45^(p^)	46.4 ± 2^(p^)	74.05 ± 2.45	44.65 ± 1.15	41.25 ± 1.25

^(p)Statistically significant change; A: infected and given methanolic extract (100 mg/kg); B: infected and given methanolic extract (200 mg/kg); C: infected and given pyrimethamine; D: infected and given PBS; E: not infected but given extract (200 mg/kg); F: not infected but given PBS.