Antimalarial Efficacy and Safety of Senna occidentalis (L.) Link Root Extract in Plasmodium berghei-Infected BALB/c Mice
Table 7
Liver function indices in berghei-infected and uninfected BALB/c mice administered with Senna occidentalis methanolic root extract.
Liver function parameters
Experimental groups
A
B
C
D
E
F
Total bilirubin (Umol/L)
5.7 ± 0.1(p)
6.55 ± 0.25(p)
5.4 ± 0.3(p)
10.75 ± 0.25
2.4 ± 0.1
2.15 ± 0.15
Direct bilirubin (Umol/L)
2.4 ± 0.2(p)
3.1 ± 0.1(p)
2.15 ± 0.15(p)
5.15 ± 0.25
1.25 ± 0.25
1.1 ± 0.2
Total proteins (G/L)
70.2 ± 1.1
71.3 ± 0.4
66.75 ± 1.75
71.65 ± 1.65
64.85 ± 1.65
63.25 ± 1.35
Albumin (G/L)
19.8 ± 1.4
18.65 ± 4.13
19.1 ± 0.3
17.85 ± 1.85
22.3 ± 1.7
19.05 ± 1.05
AST (U/L)
227 ± 4
224.25 ± 2.25
190.65 ± 7.35
251.4 ± 4.4
138.25 ± 3.25
130.5 ± 2.5
ALT (U/L)
109.85 ± 1.15
109.4 ± 1
108.3 ± 2.7
116.75 ± 2.95
94.35 ± 0.85
97.9 ± 2.1
ALP (U/L)
256.65 ± 6.95(p)
282.4 ± 11.2(p)
272.1 ± 2.9(p)
342 ± 6.8
203.95 ± 5.85
207.55 ± 3.83
(p)Statistically significant change; A: infected and given methanolic extract (100 mg/kg); B: infected and given methanolic extract (200 mg/kg); C: infected and given pyrimethamine; D: infected and given PBS; E: not infected but given extract (200 mg/kg); F: not infected but given PBS.
