Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer

Table 1

Clinical characteristics and LARS and DKK4 expressions in the enrolled CRC patients.

Characteristics		(%)
Sex
Men	368	(57.3%)
Women	274	(42.7%)
Age (year)
<65	356	(55.5%)
≥65	286	(44.5%)
Grade
Well differentiated	359	(55.9%)
Moderately differentiated	244	(38.0%)
Poorly differentiated and undifferentiated	39	(6.1%)
Size (cm)
<5	238	(37.1%)
≥5	404	(62.9%)
Location
Left side (R/S/D)	506	(78.8%)
Right side (T/A/C)	136	(21.2%)
TNM stage
0+I+II	359	(55.9%)
III+IV	283	(44.1%)
Tumor invasion
T1-T3	615	(95.8%)
T4	27	(4.2%)
N stage
0	369	(57.5%)
1	178	(27.7%)
2	95	(14.8%)
LN metastasis
(-)	369	(57.5%)
(+)	273	(42.5%)
Metastasis
(-)	604	(94.1%)
(+)	38	(5.9%)
LARS
Low expression	174	(27.1%)
High expression	468	(72.9%)
DKK4
Low expression	148	(23.1%)
High expression	494	(76.9%)

Abbreviations: LARS: leucyl-tRNA synthetase; DKK4: Dickkopf 4; LN: lymph node; TNM: tumor-node-metastasis; R: rectum; S: sigmoid colon; D: descending colon; T: transverse colon; A: ascending colon; C: cecum.