Research Article
Dickkopf 4 Alone and in Combination with Leucyl-tRNA Synthetase as a Good Prognostic Biomarker for Human Colorectal Cancer
Table 2
The relationship between clinical characteristics and immunohistochemistry expressions.
| | Characteristics | LARS expression | DKK4 expression | | Low | High | value | Low | High | value | | No. of patients (%) | No. of patients (%) | No. of patients (%) | No. of patients (%) |
| | Sex | | | | | | | | Men | 101 (27.4) | 267 (72.6) | 0.858 | 77 (20.9) | 291 (79.1) | 0.155 | | Women | 73 (26.6) | 201 (73.4) | | 71(25.9) | 203 (74.1) | | | Age | | | | | | | | <65 | 93 (26.1) | 263 (73.9) | 0.533 | 79 (22.2) | 277 (77.8) | 0.573 | | ≥65 | 81 (28.3) | 205 (71.7) | | 69 (24.1) | 217 (75.9) | | | Grade | | | | | | | | Well differentiated | 102 (28.4) | 257 (71.6) | 0.702 | 78 (21.7) | 281 (78.3) | 0.219 | | Moderately differentiated | 62 (25.4) | 182 (74.6) | | 64 (26.2) | 180 (73.8) | | | Poorly differentiated and undifferentiated | 10 (25.6) | 29 (74.4) | | 6 (15.4) | 33 (84.6) | | | Size (cm) | | | | | | | | <5 | 58 (24.4) | 180 (75.6) | 0.270 | 46 (19.3) | 192(80.7) | 0.099 | | ≥5 | 116 (28.7) | 288 (71.3) | | 102 (25.2) | 302 (74.8) | | | Location | | | | | | | | Left side (R/S/D) | 142 (28.1) | 364 (71.9) | 0.329 | 122 (24.1) | 384 (75.9) | 0.252 | | Right side (T/A/C) | 32 (23.5) | 104 (76.5) | | 26 (19.1) | 110 (80.9) | | | TNM stage | | | | | | | | 0+I+II | 117 (32.6) | 242(67.4) | <0.001 | 72 (20.1) | 287 (79.9) | 0.048 | | III+IV | 57 (20.1) | 226 (79.9) | | 76 (26.9) | 207 (73.1) | | | Tumor invasion | | | | | | | | T1-T3 | 169 (27.5) | 446 (72.5) | 0.381 | 139 (22.6) | 476 (77.4) | 0.240 | | T4 | 5 (18.5) | 22 (81.5) | | 9 (33.3) | 18 (66.7) | | | N stage | | | | | | | | 0 | 119 (32.2) | 250 (67.8) | 0.003 | 75 (20.3) | 294 (79.7) | 0.022 | | 1 | 35 (19.7) | 143 (80.3) | | 41 (23.0) | 137 (77.0) | | | 2 | 20 (21.1) | 75 (78.9) | | 32 (33.7) | 63 (66.3) | | | LN metastasis | | | | | | | | (-) | 119 (32.2) | 250 (67.8) | 0.001 | 75 (20.3) | 294 (79.7) | 0.059 | | (+) | 55 (20.1) | 218 (79.9) | | 73 (26.7) | 200 (73.3) | | | Metastasis | | | | | | | | (-) | 168 (27.8) | 436 (72.2) | 0.132 | 139 (23.0) | 465 (77.0) | 1.000 | | (+) | 6 (15.8) | 32(84.2) | | 9 (23.7) | 29 (76.3) | |
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Abbreviations: LARS: leucyl-tRNA synthetase; DKK4: Dickkopf 4; LN: lymph node; TNM: tumor-node-metastasis; R: rectum; S: sigmoid colon; D: descending colon; T: transverse colon; A: ascending colon; C: cecum. value is based on the chi-squared test. , , and . |
