Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of <sup>18</sup>F-Fluoromisonidazole and <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography

<div>Schematic for the metabolic trapping of fluorodeoxyglucose in tumor cells. Fluorine-18-fluorodeoxyglucose (<sup>18</sup>F-FDG) is accumulated in tumor cells via glucose transporter and is phosphorylated by hexokinase (HK). Glucose-6-phosphatase counteracts HK phosphorylation. Glucose-6-phosphate is consumed for energy production although FDG is not metabolized. G6P: glucose-6-phosphate; G6Pase: glucose-6-phosphatase; HK: hexokinase; TCA: tricarboxylic acid; <sup>18</sup>F-FDG: fluorine-18-fluorodeoxyglucose; <sup>18</sup>F-FDG6P: fluorine-18-fluorodeoxyglucose-6-phosphate.</div>

BioMed Research International

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Figure 1

Figure 1: Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of <sup>18</sup>F-Fluoromisonidazole and <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography 

Figure 1 | Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F-Fluoromisonidazole and 18F-Fluorodeoxyglucose Positron Emission Tomography 