Two Main Cancer Biomarkers as Molecular Targets of Binase Antitumor Activity

Figure 3

The protein-protein interaction of binase with EGFR and RAS proteins. (a) EGFR was immunoprecipitated from the whole cell protein extracts of BT-20 cells treated with binase (20 μg/mg cell protein extract) using either IgG (control) or anti-EGFR antibodies. (b) RAS was immunoprecipitated from the whole cell protein extracts of ROSE 199 A2/5 cells treated with binase (20 μg/mg cell protein extract) using either immunoglobulin G (IgG, control) or anti-pan Ras antibodies.

(a)

(b)