Two Main Cancer Biomarkers as Molecular Targets of Binase Antitumor Activity

Figure 4

The molecular modelling of the interaction between binase and EGFR. The structure of the extracellular domain of human EGFR (red) is shown in the (a) inactive (PDB 1nql) and (b) active (PDB 1ivo) complexes with EGF (yellow). Only one monomer of the active EGFR conformation is presented. The models of binase (blue) interaction with EGFR (red) in the (c) inactive and (d) active conformations extracted from the PDB structures 1nqlA and 1ivoA, respectively.

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