Two Main Cancer Biomarkers as Molecular Targets of Binase Antitumor Activity

Figure 7

The effect of binase, cetuximab, and zoledronic acid and their combinations on the cell viability of A549 and BT-20 cells as measured via the MTT assay. (a) The cells were incubated with binase (300 μg/mL), cetuximab (100 μg/mL), and zoledronic acid (100 μg/mL) or their combinations for 48 h. The viability of the untreated cells was taken for 100%. (b) The cells were incubated with the first agent for 24 h followed by the incubation with the second drug for 48 h at the abovementioned concentrations. The viability of the cells treated by the first agent alone for 24 h followed by the media replacement and cultivation for another 48 h was taken for 100%. Significant differences are indicated as and .

(a)

(b)