Pharmacological Manipulation of Corticotropin-Releasing Factor Receptors in the Anterior and Posterior Subregions of the Insular Cortex Differently Affects Anxiety-Like Behaviors in the Elevated Plus Maze in Rats

Figure 3

Role of CRFergic neurotransmission in the posterior IC controlling anxiety-like behaviors in the EPM. Effect of bilateral microinjection of vehicle (saline, 100 nL, ), the selective CRF₁ receptor antagonist CP376395 (5 nmol/100 nL, ), or CRF (0.1 nmol/100 nL, ) into the posterior subregion of the IC on the exploration of open and closed arms of the EPM. Treatment of the posterior IC was performed 10 min before the EPM exposure. Columns represent the . in relation to the vehicle group. One-way ANOVA followed by the Bonferroni post hoc test.