Research Article

Screening Marine Microbial Metabolites as Promising Inhibitors of Borrelia garinii: A Structural Docking Approach towards Developing Novel Lyme Disease Treatment

Table 2

Overview of the essential proteins, including their length and associated KEGG pathway ID.

Serial no.Length (amino acids)KEGG pathway IDDefinition

1.1155K03043rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
2.1124K03723mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
3.899K03070secA; preprotein translocase subunit SecA [EC:7.4.2.8]
4.849K03168topA; DNA topoisomerase I [EC:5.6.2.1]
5.810K02469gyrA; DNA gyrase subunit A [EC:5.6.2.2]
6.806K01338lon; ATP-dependent Lon protease [EC:3.4.21.53]
7.791K03217Membrane protein insertase YidC
8.669K02355fusA, GFM, EFG; elongation factor G
9.631K03086rpoD; RNA polymerase primary sigma factor
10.594K01872AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]
11.593K02316dnaG; DNA primase [EC:2.7.7.101]
12.536K23537nupA; general nucleoside transport system ATP-binding protein
13.488K01881PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]
14.455K03106SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]
15.452K02481rrp-2; response regulatory protein
16.414K01478arcA; arginine deiminase [EC:3.5.3.6]
17.389K03438mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]
18.362K01000mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
19.352K03588ftsW, spoVE; cell division protein FtsW
20.350K02836prfB; peptide chain release factor 2
21.349K15582oppC; oligopeptide transport system permease protein
22.327K00611OTC, argF, argI; ornithine carbamoyltransferase [EC:2.1.3.3]
23.279K02357tsf, TSFM; elongation factor Ts
24.215K02890RP-L22, MRPL22, rplV; large subunit ribosomal protein L22
25.197K01358clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]