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Behavioural Neurology
Volume 5, Issue 3, Pages 139-147

Single-Photon Emission Computerized Tomography (SPECT) in Neuropsychiatry: A Review

B. K. Puri1 and S. W. Lewis2

1Department of Psychiatry, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK
2Academic Department of Psychiatry, Charing Cross and Westminster Medical School, St Dunstan's Road, London W6 8RP, UK

Copyright © 1992 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cranial single-photon emission computerized tomography (SPECT or SPET) can now give regional cerebral blood flow images with a resolution approaching that of positron emission tomography (PET). In this paper, the use of high resolution SPECT neuroimaging in neuropsychiatric disorders, including Alzheimer's disease, multi-infarct dementia, Pick's disease, progressive supranuclear palsy, Korsakoff's psychosis, Creutzfeld-Jakob disease, Parkinson's disease, Huntington's disease, schizophrenia, mood disorders, obsessive–compulsive disorder, HIV infection and AIDS is reviewed. Finally, further potential research and clinical uses, based on ligand studies, are outlined.