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Behavioural Neurology
Volume 17, Issue 2, Pages 109-115
http://dx.doi.org/10.1155/2006/136945

The Validity of the Hospital Anxiety and Depression Scale and the Geriatric Depression Scale in Parkinson’s Disease

Federica Mondolo,1 Marjan Jahanshahi,2 Alessia Granà,1,3 Emanuele Biasutti,1 Emanuela Cacciatori,1 and Paolo Di Benedetto1

1Institute of Physical Medicine and Rehabilitation, Gervasutta Hospital, Via Gervasutta, 48, 33100 Udine, Italy
2Sobell Department of Motor Neuroscience & Movement Disorders, Institute of Neurology, The National Hospital for Neurology & Neurosurgery, Queen Square, London WC1N 3BG, UK
3Department of Psychology, University of Trieste, Italy

Received 10 July 2006; Accepted 10 July 2006

Copyright © 2006 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We assessed the concurrent validity of the Hospital Anxiety and Depression Scale (HADS) and the Geriatric Depression Scale (GDS) against the Hamilton Rating Scale for Depression (Ham-D) in patients with Parkinson’ disease (PD). Forty-six non-demented PD patients were assessed by a neurologist on the Ham-D. Patients also completed four mood rating scales: the HADS, the GDS, the VAS and the Face Scale. For the HADS and the GDS, Receiver Operating Characteristics (ROC) curves were obtained and the positive and negative predictive values (PPV, NPV) were calculated for different cut-off scores. Maximum discrimination between depressed and non-depressed PD patients was reached at a cut-off score of 10/11 for both the HADS and the GDS. At the same cut-off score of 10/11 for both the HADS and the GDS, the high sensitivity and NPV make these scales appropriate screening instruments for depression in PD. A high specificity and PPV, which is necessary for a diagnostic test, was reached at a cut-off score of 12/13 for the GDS and at a cut-off score of 11/12 for the HADS. The results indicate the validity of using the HADS and the GDS to screen for depressive symptoms and to diagnose depressive illness in PD.