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Behavioural Neurology
Volume 17, Issue 1, Pages 53-67

Treatment of Cognitive Impairment in Multiple Sclerosis

Susan H. Pierson1 and Nathan Griffith2

1Department of Neurology, Drake Center and University of Cincinnati, 151 West Galbraith Road, Cincinnati, OH 45216, USA
2Department of Psychology, University of Cincinnati, Cincinnati, OH 45219, USA

Received 26 April 2006; Accepted 26 April 2006

Copyright © 2006 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Cognitive impairment in multiple sclerosis is an increasingly recognized entity. This article reviews the cognitive impairment of multiple sclerosis, its prevalence, its relationship to different types of multiple sclerosis, and its contribution to long-term functional prognosis. The discussion also focuses on the key elements of cognitive dysfunction in multiple sclerosis which distinguish it from other forms of cognitive impairment. Therapeutic interventions potentially effective for the cognitive impairment of multiple sclerosis are reviewed including the effects of disease modifying therapies and the use of physical and cognitive interventions.