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Behavioural Neurology
Volume 18, Issue 4, Pages 239-243
Case Report

Right Hemisphere Involvement in Non-Fluent Primary Progressive Aphasia

Claudia Repetto,1 Rosa Manenti,2 Maria Cotelli,1 Marco Calabria,3 Orazio Zanetti,1 Barbara Borroni,4 Alessandro Padovani,4 and Carlo Miniussi1,5

1IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy
2Department of Neuroscience, Vita Salute University and San Raffaele Scientific Institute, Milan, Italy
3Department of General Psychology, University of Padua, Italy
4Department of Neurology, University of Brescia, Italy
5Department of Biomedical Sciences and Biotechnologies, University of Brescia, Italy

Received 18 February 2008; Accepted 18 February 2008

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We described a 56-years-old man with a diagnosis of “non-fluent primary progressive aphasia” (NfPPA). An accurate neuropsychological, neurological and neuroimaging evaluation was performed in order to assess clinical and behavioural features of the patient.

From a neuropsychological point of view, the patient showed a typical cognitive profile of subjects affected by NfPPA: a prominent language deficit, associated with impairments in several cognitive domains after three years from the onset of the symptomatology.

The most intriguing feature is that SPECT revealed hypoperfusion in the right frontal cortex, albeit the patient is right-handed.

This unexpected finding shows that NfPPA may arise not only from cortical abnormalities in the language-dominant left hemisphere, but also from right hemisphere involvement in a right hander (crossed aphasia).