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Behavioural Neurology
Volume 18, Issue 3, Pages 135-142
Clinical Note

Movements Execution in Amnestic Mild Cognitive Impairment and Alzheimer’s Disease

Rosolino Camarda,1 Cecilia Camarda,1 Roberto Monastero,1 Silvia Grimaldi,1 Lawrence K. C. Camarda,1 Carmela Pipia,1 Carlo Caltagirone,2 and Massimo Gangitano1

1Laboratory of Epidemiology and Psychology of Aging and Dementia, Section of Neurology, Department of Clinical Neuroscience, University of Palermo, Palermo, Italy
2Department of Neurology, University "Tor Vergata", and Fondazione "Santa Lucia" IRCCS, Rome, Italy

Received 14 August 2007; Accepted 14 August 2007

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We evaluated the relationship between motor and neuropsychological deficits in subjects affected by amnestic Mild Cognitive Impairment (aMCI) and early Alzheimer’s Disease (AD). Kinematics of goal-directed movement of aMCI and AD subjects were compared to those of age-matched control subjects. AD showed a slowing down of motor performance compared to aMCI and controls. No relationships were found between motor and cognitive performances in both AD and aMCI. Our results suggest that the different motor behaviour between AD and aMCI cannot be related to memory deficits, probably reflecting the initial degeneration of parietal-frontal circuits for movement planning. The onset of motor dysfunction in early AD could represent the transition from aMCI to AD.