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Behavioural Neurology
Volume 18, Issue 2, Pages 131-134

Neuropsychological Findings of Extrapontine Myelinolysis without Central Pontine Myelinolysis

Jung Im Seok, Dong Kuck Lee, Min Gu Kang, and Jae Han Park

Department of neurology, School of Medicine, Catholic University of Daegu, Korea

Received 25 May 2007; Accepted 25 May 2007

Copyright © 2007 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM) are well recognized syndromes related to the rapid correction of hyponatremia, which are reported to show brain stem signs and various movement disorders. Cognitive dysfunction and neuropsychological findings, however, have seldom been reported. Cognitive manifestations in osmotic myelinolysis may have been underestimated due to the prominent brain stem symptoms and movement disorders. We report a case of EPM without CPM and describe the neuropsychological findings of EPM. The absence of CPM in this case made it possible to test neuropsychological function in the acute stage.

Neuropsychological testing showed severe impairment of attention, verbal and visual memory, visuospatial function, and frontal/executive function. Language and language-related functions were normal except naming.