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Behavioural Neurology
Volume 20, Issue 1-2, Pages 1-9

Effects on Cognition of Stereotactic Lesional Surgery For the Treatment of Tremor in Multiple Sclerosis

Marjan Jahanshahi,1 Socorro Pieter,1 Sundus H. Alusi,2,7 Catherine R. G. Jones,1,3 Scott Glickman,4,7 John Stein,5 Tipu Aziz,6 and Peter G. Bain7

1Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, The National Hospital for Neurology & Neurosurgery, London, UK
2The Walton Centre for Neurology and Neurosurgery, NHS Trust, Merseyside, Liverpool, UK
3Current address: Behavioural and Brain Sciences Unit, UCL Institute of Child Health, London, UK
4Current address: Buckinghamshire Chilterns University College, Chalfont St. Giles, Buckinghamshire, UK
5Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
6Department of Neurosurgery, Radcliffe Infirmary, Oxford, UK
7The Movement Disorders and Neurostimulation Unit, Department of Neuroscience, Charing Cross Hospital and Division of Neuroscience and Mental Health, Imperial College London, London, UK

Received 12 May 2009; Accepted 12 May 2009

Copyright © 2008 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective: To assess the effect of stereotactic lesional surgery for treatment of tremor in multiple sclerosis on cognition.

Methods: Eleven patients (3 males, 8 females) with multiple sclerosis participated in the study. Six subjects comprised the surgical group and five the matched control group. All patients were assessed at baseline and three months using a neuropsychological test battery that included measures of intellectual ability, memory, language, perception and executive function.

Results: There were no significant differences between the surgical and control groups and no change from pre to post testing except for a decline in scores on the Mini-Mental State Examination (MMSE), WAIS-R Digit Span and Verbal Fluency in the surgical group.

Conclusions: The results indicate that stereotactic lesional surgery does not result in major cognitive impairment in multiple sclerosis. However, the decline in MMSE scores, digit span and verbal fluency require further investigation in a larger sample.