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Behavioural Neurology
Volume 25, Issue 4, Pages 303-310

Post-Stroke Depression: Main Phenomenological Clusters and their Relationships with Clinical Measures

Davide Quaranta, Camillo Marra, and Guido Gainotti

Research Center for Neuropsychology, Department of Neuroscience, Catholic University, Rome, Italy

Received 17 February 2012; Accepted 17 February 2012

Copyright © 2012 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives: To investigate the principal psychopathological dimensions of post-stroke depression (PSD) through the assessment of the factorial structure of the Post-Stroke Depression Rating Scale (PSDRS).

Methods: We enrolled ninety-eight subjects with PSD, who underwent the PSDRS, MMSE and Barthel Index. Information about demographic, clinical, and neuroanatomical factors was collected.

Results: The factor analysis extracted three factors accounting for 63.4% of the total variance, and identified as: (1) “Depressive and Anxious Symptoms“ (DAS); (2) “Lack of Emotional Control” (LEC); 3) “Reduced Motivation” (RM). On multivariate statistics, DAS severity was predicted by previous history of mood disorders and Barthel Index; LEC severity was predicted by Barthel Index; RM severity was predicted by age.

Conclusions: The PSDRS displayed a reliable factor structure that agreed with previous interpretation of PSD. In particular, core depressive symptoms seem to be related to premorbid personality and functional status, whereas apathy/anhedonia may be connected to brain aging.