Behavioural Neurology

Behavioural Neurology / 2013 / Article
Special Issue

Includes Special Section: Abstracts from the Joint Meeting of the FESN/GNP, Sept. 12-14, 2013, Berlin, Germany

View this Special Issue

Open Access

Volume 27 |Article ID 103105 | https://doi.org/10.3233/BEN-2012-110234

Mohammad Fakhri, Hajir Sikaroodi, Farid Maleki, Hossein Ghanaati, Mohammad Ali Oghabian, "Impacts of Normal Aging on Different Working Memory Tasks: Implications from an fMRI Study", Behavioural Neurology, vol. 27, Article ID 103105, 10 pages, 2013. https://doi.org/10.3233/BEN-2012-110234

Impacts of Normal Aging on Different Working Memory Tasks: Implications from an fMRI Study

Received04 Sep 2012
Accepted04 Sep 2012

Abstract

Purpose: To evaluate patterns of activation, convergence and divergence of three functional magnetic resonance imaging (fMRI) Working Memory (WM) tasks in two different age groups. We want to understand potential impact of task and subjects’ age on WM activations as well as most important areas with regard to WM functions.Materials and Methods: Thirty-five healthy volunteers completed visual, verbal, and novel auditory WM tasks. The subjects were selected from age extremes to depict possible impact of normal aging. General Linear Model was used to report significant activations and the effect of group. One-to-one comparison of the tasks and Combined Task Analysis was also performed.Results: Most of the observed differences between the tasks were seen in areas that were responsible for feature processing. Frontal regions were mainstay activation areas, regardless of the utilized stimulus. We found an age-related reduction in activity of visual (in visually-presented tasks) and auditory (in auditory task) cortices but an age-related increase in prefrontal cortex for all tasks.Conclusion: Regardless of the type of the task stimuli, frontal regions are the most important activation areas in WM processing. These areas are also main targets of age-related changes with regard to activation patterns. Our results also indicate that prefrontal overactivity in working memory might be a compensatory effort to mask age-related decline in sensory processing.

Copyright © 2013 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


More related articles

 PDF Download Citation Citation
 Order printed copiesOrder
Views681
Downloads597
Citations

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.