Behavioural Neurology

Behavioural Neurology / 2013 / Article

Case Report | Open Access

Volume 27 |Article ID 278976 | https://doi.org/10.3233/BEN-120299

Susy Paolini, Lucia Paciaroni, Antonio Manca, Roberto Rossi, Daniela Fornarelli, Stefano F. Cappa, Angela M. Abbatecola, Osvaldo Scarpino, "Change of Accent as an Atypical Onset of non Fluent Primary Progressive Aphasia", Behavioural Neurology, vol. 27, Article ID 278976, 7 pages, 2013. https://doi.org/10.3233/BEN-120299

Change of Accent as an Atypical Onset of non Fluent Primary Progressive Aphasia

Received01 Feb 2013
Accepted01 Feb 2013

Abstract

Language disorders can be the first symptom of many neurodegenerative diseases, including Alzheimer's disease (AD) and primary progressive aphasia (PPA). The main variants of PPA are: the non-fluent/agrammatic variant, the semantic variant and the logopenic variant.Several additional variants of PPA, however, have been described and are considered as atypical presentations.We describe the case of a woman presenting a progressive isolated language disturbance, characterized by an early dysprosodia, phonological and semantic paraphasias, agrammatism, impairment in repetition, writing of non-words and sentence comprehension. This clinical picture pointed to an atypical presentation of the non-fluent variety. The frequent symptom overlap between the different variants of PPA, most likely reflecting differences in the topography of the pathological changes, needs to be considered in the definition of diagnostic criteria.

Copyright © 2013 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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