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Behavioural Neurology
Volume 27, Issue 2, Pages 201-212
http://dx.doi.org/10.3233/BEN-120278

Decrease of Mutual Information in Brain Electrical Activity of Patients with Relapsing-Remitting Multiple Sclerosis

Bruno Lenne,1,3 Jean-Luc Blanc,2 Jean-Louis Nandrino,3 Philippe Gallois,1 Patrick Hautecæur,1 and Laurent Pezard2

1Service de Neurologie, Hôpital Universitaire Saint-Philibert – GHICL, Lomme, France
2INS, UMR 1106 Inserm, Aix-Marseille Université, Marseille, France
3URECA EA 1059, Université de Lille Nord de France, Lille, France

Received 9 November 2012; Accepted 9 November 2012

Copyright © 2013 Hindawi Publishing Corporation and the authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The disturbance of cortical communication has been hypothesized as an important factor in the appearance of cognitive impairment in (MS). Cortical communication is quantified here in control subjects and patients with relapsing-remitting multiple sclerosis (RRMS) on the basis of mean coherence in the δ, θ, α, β and γ bands and using mutual information computed between pairs of bipolar EEG signals recorded during resting condition. Each patient received also a cognitive assessment using a battery of neuropsychological tests specific to cognitive deficits in MS.

No difference was observed for the coherence indices whereas inter-hemispheric and right hemisphere mutual information is significantly lower in patients with MS than in control subjects. Moreover, inter-hemispheric mutual information decrease significantly with illness duration and right mutual information differentiate cognitively deficient and non-deficient patients.

Mutual information allows to quantify the cortical communication in patients with RRMS and is related to clinical characteristics.

Cortical communication quantified in a resting state might be a potential marker for the neurological damage induced by RRMS.