Two different sporadic CJD patients (patient 1, a and b; patient 2, c and d) showing in patient 1 bilateral caudate nucleus and putaminal (arrows) and to a lesser degree posteromesial and pulvinar thalamic (arrowheads) hyperintensities on DWI (a) and FLAIR imaging (b) and in patient 2 bilateral posteromesial thalamic (arrowheads) and multifocal cortical (arrows) hyperintensities on DWI (c), seen as hypointensity on ADC map (d). Anterior predominance of the thalamic involvement can be seen in patient 2.
