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Behavioural Neurology
Volume 2014 (2014), Article ID 231469, 7 pages
http://dx.doi.org/10.1155/2014/231469
Research Article

Apathy and Emotion-Based Decision-Making in Amnesic Mild Cognitive Impairment and Alzheimer’s Disease

1 Centre d’Investigation Clinique, Centre Hospitalier Universitaire Montpellier, 80 avenue Augustin Fliche, 34295 Montpellier Cedex 5, France
2Laboratoire Epsylon, EA 4556, Université Montpellier, rue du Professeur Henri Serre, 34000 Montpellier, France
3Consultations Mémoire, CH Val d’Ariège, BP 01, 09017 Foix, France
4Service Universitaire de Psychiatrie Adulte, Centre Hospitalier Universitaire Montpellier, 39 avenue Charles Flahault, 34295 Montpellier Cedex 5, France

Received 23 November 2013; Revised 26 May 2014; Accepted 2 June 2014; Published 22 June 2014

Academic Editor: Oliver Wirths

Copyright © 2014 Sophie Bayard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Apathy and reduced emotion-based decision-making are two behavioral modifications independently described in Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). Objectives. The aims of this study were to investigate decision-making based on emotional feedback processing in AD and aMCI and to study the impact of reduced decision-making performances on apathy. Methods. We recruited 20 patients with AD, 20 participants with aMCI, and 20 healthy controls. All participants completed the Lille apathy rating scale (LARS) and the Iowa gambling task (IGT). Results. Both aMCI and AD participants had reduced performances on the IGT and were more apathetic compared to controls without any difference between aMCI and AD groups. For the entire sample, LARS initiation dimension was related to IGT disadvantageous decision-making profile. Conclusions. We provide the first study showing that both aMCI and AD individuals make less profitable decisions than controls, whereas aMCI and AD did not differ. Disadvantageous decision-making profile on the IGT was associated with higher level of apathy on the action initiation dimension. The role of an abnormal IGT performance as a risk factor for the development of apathy needs to be investigated in other clinical populations and in normal aging.