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Behavioural Neurology
Volume 2014, Article ID 268967, 11 pages
Research Article

Patients with Mild Cognitive Impairment Display Reduced Auditory Event-Related Delta Oscillatory Responses

1Brain Dynamics and Multidisciplinary Research Center, Dokuz Eylul University, Balçova, 35340 Izmir, Turkey
2Department of Neurosciences, Dokuz Eylul University, 35340 Izmir, Turkey
3Department of Neurology, Dokuz Eylul University, 35340 Izmir, Turkey
4Department of Psychology, Istanbul Arel University, 34295 Istanbul, Turkey
5Brain Dynamics, Cognition and Complex Systems Research Center Istanbul Kültür University, 35156 Istanbul, Turkey
6Department of Neurology, Maltepe University, 34844 Istanbul, Turkey

Received 28 September 2013; Revised 23 February 2014; Accepted 26 February 2014; Published 27 March 2014

Academic Editor: Veit Roessner

Copyright © 2014 Pınar Kurt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Event-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory event-related delta oscillations of MCI subjects. Method. The study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age- and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from , Fz, , , , , , Pz, , , Oz, and locations. The maximum peak-to-peak amplitudes for each subject’s averaged delta response (0.5–2.2 Hz) were measured. Results. The amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F(1.41) = 4.84, ), indicating a larger delta response for healthy controls than MCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites , Fz, , , , and Pz. Discussion. Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.