Pain in Parkinson's Disease Associated with COMT Gene Polymorphisms

Table 1

COMT genotype and PD with or without pain.

	PD with pain (𝑁=55)	PD without pain (𝑁=42)	AD; OR (95% CI)	𝑃 value (AD)	AR; OR (95% CI)	𝑃 value (AR)
rs4633
CC	25 (0.455)	22 (0.524)	0.776 (0.291–2.067)	0.612
CT	27 (0.491)	18 (0.429)
TT	3 (0.055)	2 (0.048)			1.582 (0.222–11.294)	0.648
rs6267
GG	33 (0.600)	35 (0.833)	0.216 (0.068–0.688)	0.010 *
GT	20 (0.364)	6 (0.143)
TT	2 (0.036)	1 (0.024)			0.484 (0.028–8.487)	0.619

Binary logistic regression was used; covariates were age, sex, onset age, duration of disease, duration of L-Dopa medication, and UPDRS. *𝑃<0.05 after FDR correction (aF = 0.010 * 8/2); COMT: catechol-O-methyltransferase, PD: Parkinson’s disease, AD: autosomal dominant inheritance, AR: autosomal recessive inheritance, and OR: odds ratio.