Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Treatment</td><td align="center">Neurite length (μm)</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">Control</td><td align="center">799.0 ± 66.70</td></tr><tr><td align="left">Glutamate (20 mM)</td><td align="center">190.1 ± 12.83**</td></tr><tr><td align="left">Glutamate + insulin (0.1 μM )</td><td align="center">640.46 ± 44.32#</td></tr><tr><td align="left">Glutamate + insulin (1 μM)</td><td align="center">552.22 ± 22.90##</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>Values are expressed as mean ± SEM of three tests in triplicate. Statistical analysis was done by using one-way ANOVA followed by Tukey’s multiple comparison test. ***P &lt; 0.001 compared to control group, #P &lt; 0.05 compared to glutamate group, and ##P &lt; 0.01 compared to glutamate group. </td></tr></table>

Effect of treatments on length of neurites.

Behavioural Neurology

tab5

Table 5

Table 5: Insulin Blocks Glutamate-Induced Neurotoxicity in Differentiated SH-SY5Y Neuronal Cells 