Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat

Figure 3

Food intake and metabolic rate. The animals’ average food consumption and feces production were periodically measured to follow the impact of chronic continuous MFB-DBS. Following the onset and up to 16 days after stimulation, MFB-HFS animals consumed approximately 25% less food pellets compared to the unstimulated animals. However, beyond this initial period, the food intake recovered to normal levels even with continuous stimulation (a). Average feces production over time was stable, but an approximate reduction of 25% was observed during the first week of MFB-HFS in the DBS C group. See text for more detail. compared to all other groups during the same period.

(a) Food intake

(b) Feces weight